Prior to running a sample on a flash instrument/column it is important to determine the optimum solubility, selectivity and resolution by TLC. The following solvent systems provide a wide range of selectivities and are a useful screening tool. Valuable information is obtained by running the sample in several mobile phases and will improve the odds of obtaining purity using Flash. It is also useful to create a weak and strong polarity for each of the mobile phases to obtain additional data points.

The TLC plate which correlates to puriFLash HC & HP silica columns is available from Interchim, part number PFT-15341-1. For additional information, click here.